Vitamin B-12 and the Gastrointestinal Microbiome: A Systematic Review.

ABSTRACT: Vitamin B-12 deficiency is a major public health problem affecting individuals across the lifespan, with known hematological, neurological, and obstetric consequences. Emerging evidence suggests that vitamin B-12 may have an important role in other aspects of human health, including the composition and function of the gastrointestinal (gut) microbiome. Vitamin B-12 is synthesized and utilized by bacteria in the human gut microbiome and is required for over a dozen enzymes in bacteria, compared to only 2 in humans. However, the impact of vitamin B-12 on the gut microbiome has not been established. This systematic review was conducted to examine the evidence that links vitamin B-12 and the gut microbiome. A structured search strategy was used to identify in vitro, animal, and human studies t

SUBMITTER: Guetterman HM 

PROVIDER: S-EPMC8970816 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature