Prostate Cancer Susceptibility Loci Identified in GATA2 and ZMIZ1 in Chinese Population.

ABSTRACT:

Background

Common genetic risk variants for prostate cancer (PCa) have been identified at approximately 170 loci using genome-wide association studies (GWAS), most of which were identified in European populations. Recently, GWAS were applied to a large Japanese cohort and identified 12 novel susceptibility loci associated with PCa risk. In this study, we aim to investigate PCa susceptibility loci in the Chinese population. The study data will be used to promote PCa risk control in China.

Methods

A total of 235 PCa patients and 252 control subjects (all unrelated) were enrolled in this case-control PCa study. Nine single nucleotide polymorphisms (SNPs) were genotyped in GATA2 (rs73862213, rs2335052, and rs10934857), ZMIZ1 (rs704017, rs77911174, and rs3740259), a

SUBMITTER: Zhang HJ 

PROVIDER: S-EPMC8970932 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature