Change in plasma α-tocopherol associations with attenuated pulmonary function decline and with CYP4F2 missense variation.

ABSTRACT:

Background

Vitamin E (vitE) is hypothesized to attenuate age-related decline in pulmonary function.

Objectives

We investigated the association between change in plasma vitE (∆vitE) and pulmonary function decline [forced expiratory volume in the first second (FEV1)] and examined genetic and nongenetic factors associated with ∆vitE.

Methods

We studied 1144 men randomly assigned to vitE in SELECT (Selenium and Vitamin E Cancer Prevention Trial). ∆vitE was the difference between baseline and year 3 vitE concentrations measured with GC-MS. FEV1 was measured longitudinally by spirometry. We genotyped 555 men (vitE-only arm) using the Illumina Expanded Multi-Ethnic Genotyping Array (MEGAex). We used mixed-effects linear regression modeling to examine the ∆vitE-FEV1 associati

SUBMITTER: Xu J 

PROVIDER: S-EPMC8970985 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature