Preconception caffeine metabolites, caffeinated beverage intake, and fecundability.

ABSTRACT:

Background

Caffeine is the most frequently used psychoactive substance in the United States and >90% of reproductive-age women report some amount of intake daily. Despite biological plausibility, previous studies on caffeine and fecundability report conflicting results. Importantly, prior studies measured caffeine exposure exclusively by self-report, which is subject to measurement error and does not account for factors that influence caffeine metabolism.

Objectives

Our objective was to examine associations between preconception serum caffeine metabolites, caffeinated beverage intake, and fecundability.

Methods

Participants included 1228 women aged 18-40 y with a history of 1-2 pregnancy losses in the EAGeR (Effects of Aspirin in Gestation and Reproduction) trial. We

SUBMITTER: Purdue-Smithe AC 

PROVIDER: S-EPMC8970989 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature