Multiple Dietary Vitamin K Forms Are Converted to Tissue Menaquinone-4 in Mice.

ABSTRACT:

Background

Vitamin K is a term that comprises a family of structurally related quinones, phylloquinone (PK) and the menaquinones (MKn), that share a common naphthoquinone ring but vary in sidechain length (n) and saturation. Dietary PK is a biosynthetic precursor to tissue menaquinone-4 (MK4), but little is known about the absorption and metabolism of dietary MKn.

Objective

To characterize the absorption and metabolism of dietary MKn relative to PK.

Methods

In the 4-week diet study, 10-week-old male and female C57BL/6 mice were pair-fed a vitamin K deficient diet (control) or a diet supplemented with 5.0 μmol/kg total PK, MK4, and/or MK9 (separately and in combination). In the 1-week stable isotope study, 12-week-old mice were pair-fed diets containing 2.2 μmol/kg PK

SUBMITTER: Ellis JL 

PROVIDER: S-EPMC8971004 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature