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Flavonoids Inhibit Cancer by Regulating the Competing Endogenous RNA Network.


ABSTRACT: Flavonoids are present in a wide range of plants. They have been used in the treatment of cancer, but the mechanism underlying this activity is unclear. In recent years, microRNA (miRNA) and long non-coding RNA (lncRNA) levels have been observed to differ between normal tissues and cancer cells, and both types of RNA have been shown to have a role in tumor treatment. In addition, flavonoids have been proven to regulate miRNAs and LncRNAs in the treatment of cancer. The competing endogenous RNA (ceRNA) network is a complex post-transcriptional regulatory mechanism in cells, in which coding and non-coding RNAs competitively bind miRNAs to regulate messenger RNAs (mRNAs). This review focused on the role of the ceRNA network in the treatment of cancer by flavonoids.

SUBMITTER: Li C 

PROVIDER: S-EPMC8971295 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Flavonoids Inhibit Cancer by Regulating the Competing Endogenous RNA Network.

Li Chengshun C   Li Xiaolan X   Jiang Ziping Z   Wang Dongxu D   Sun Liqun L   Li Jiaqi J   Han Yang Y  

Frontiers in oncology 20220318


Flavonoids are present in a wide range of plants. They have been used in the treatment of cancer, but the mechanism underlying this activity is unclear. In recent years, microRNA (miRNA) and long non-coding RNA (lncRNA) levels have been observed to differ between normal tissues and cancer cells, and both types of RNA have been shown to have a role in tumor treatment. In addition, flavonoids have been proven to regulate miRNAs and LncRNAs in the treatment of cancer. The competing endogenous RNA (  ...[more]

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