Profiling hymenopteran venom toxins: Protein families, structural landscape, biological activities, and pharmacological benefits.

ABSTRACT: Hymenopterans are an untapped source of venom secretions. Their recent proteo-transcriptomic studies have revealed an extraordinary pool of toxins that participate in various biological processes, including pain, paralysis, allergic reactions, and antimicrobial activities. Comprehensive and clade-specific campaigns to collect hymenopteran venoms are therefore needed. We consider that data-driven bioprospecting may help prioritise sampling and alleviate associated costs. This work established the current protein landscape from hymenopteran venoms to evaluate possible sample bias by studying their origins, sequence diversity, known structures, and biological functions. We collected all 282 reported hymenopteran toxins (peptides and proteins) from the UniProt database that we clustered into 2

SUBMITTER: Guido-Patino JC 

PROVIDER: S-EPMC8971319 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature