Effects of oral losartan administration on homeostasis of articular cartilage and bone in a rabbit model.

ABSTRACT:

Background and aims

Previous work has shown that oral losartan can enhance microfracture-mediated cartilage repair in a rabbit osteochondral defect injury model. In this study, we aimed to determine whether oral losartan would have a detrimental effect on articular cartilage and bone homeostasis in the uninjured sides.

Methods

New Zealand rabbits were divided into 4 groups including normal uninjured (Normal), contralateral uninjured side of osteochondral defect (Defect), osteochondral defect plus microfracture (Microfracture) and osteochondral defect plus microfracture and losartan oral administration (10 mg/kg/day) (Losartan). Rabbits underwent different surgeries and treatment and were sacrificed at 12 weeks. Both side of the normal group and uninjured side of treatment gr

SUBMITTER: Deng Z 

PROVIDER: S-EPMC8971351 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature