Four novel candidate causal variants for deficient homozygous haplotypes in Holstein cattle.

ABSTRACT: Mendelian variants can determine both insemination success and neonatal survival and thus influence fertility and rearing success of cattle. We present 24 deficient homozygous haplotype regions in the Holstein population of Switzerland and provide an overview of the previously identified haplotypes in the global Holstein breed. This study encompasses massive genotyping, whole-genome sequencing (WGS) and phenotype association analyses. We performed haplotype screenings on almost 53 thousand genotyped animals including 114 k SNP data with two different approaches. We revealed significant haplotype associations to several survival, birth and fertility traits. Within haplotype regions, we mined WGS data of hundreds of bovine genomes for candidate causal variants, which were subsequently evalua

SUBMITTER: Hafliger IM 

PROVIDER: S-EPMC8971413 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature