Selective loss of kisspeptin signaling in oocytes causes progressive premature ovulatory failure.
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ABSTRACT:
SUBMITTER: Ruohonen ST
PROVIDER: S-EPMC8971646 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
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Selective loss of kisspeptin signaling in oocytes causes progressive premature ovulatory failure.
Ruohonen Suvi T ST Gaytan Francisco F Usseglio Gaudi Andrea A Velasco Inmaculada I Kukoricza Krisztina K Perdices-Lopez Cecilia C Franssen Delphine D Guler Ipek I Mehmood Arfa A Elo Laura L LL Ohlsson Claes C Poutanen Matti M Tena-Sempere Manuel M
Human reproduction (Oxford, England) 20220401 4
<h4>Study question</h4>Does direct kisspeptin signaling in the oocyte have a role in the control of follicular dynamics and ovulation?<h4>Summary answer</h4>Kisspeptin signaling in the oocyte plays a relevant physiological role in the direct control of ovulation; oocyte-specific ablation of kisspeptin receptor, Gpr54, induces a state of premature ovulatory failure in mice that recapitulates some features of premature ovarian insufficiency (POI).<h4>What is known already</h4>Kisspeptins, encoded ...[more]
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