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Uterine fluid microRNAs are dysregulated in women with recurrent implantation failure.


ABSTRACT:

SUBMITTER: von Grothusen C 

PROVIDER: S-EPMC8971651 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Uterine fluid microRNAs are dysregulated in women with recurrent implantation failure.

von Grothusen Carolina C   Frisendahl Caroline C   Modhukur Vijayachitra V   Lalitkumar Parameswaran Grace PG   Peters Maire M   Faridani Omid R OR   Salumets Andres A   Boggavarapu Nageswara Rao NR   Gemzell-Danielsson Kristina K  

Human reproduction (Oxford, England) 20220401 4


<h4>Study question</h4>Is the composition of microRNAs (miRNAs) in uterine fluid (UF) of women with recurrent implantation failure (RIF) different from that of healthy fertile women?<h4>Summary answer</h4>The composition of miRNAs in UF of women with RIF is different from that of healthy fertile women and the dysregulated miRNAs are associated with impaired endometrial receptivity and embryo implantation.<h4>What is known already</h4>It has previously been demonstrated that the miRNAs secreted f  ...[more]

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