Sperm acquire epididymis-derived proteins through epididymosomes.
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ABSTRACT:
SUBMITTER: Barrachina F
PROVIDER: S-EPMC8971652 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Publications
Sperm acquire epididymis-derived proteins through epididymosomes.
Barrachina F F Battistone M A MA Castillo J J Mallofré C C Jodar M M Breton S S Oliva R R
Human reproduction (Oxford, England) 20220401 4
<h4>Study question</h4>Are epididymosomes implicated in protein transfer from the epididymis to spermatozoa?<h4>Summary answer</h4>We characterized the contribution of epididymal secretions to the sperm proteome and demonstrated that sperm acquire epididymal proteins through epididymosomes.<h4>What is known already</h4>Testicular sperm are immature cells unable to fertilize an oocyte. After leaving the testis, sperm transit along the epididymis to acquire motility and fertilizing abilities. It i ...[more]
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