RNA 5-Methylcytosine Regulators Contribute to Metabolism Heterogeneity and Predict Prognosis in Ovarian Cancer.

ABSTRACT: 5-Methylcytosine (m⁵C) is an abundant and highly conserved modification in RNAs. The dysregulation of RNA m⁵C methylation has been reported in cancers, but the regulatory network in ovarian cancer of RNA m⁵C methylation-related genes and its implication in metabolic regulation remain largely unexplored. In this study, RNA-sequencing data and clinical information of 374 ovarian cancer patients were downloaded from The Cancer Genome Atlas database, and a total of 14 RNA m⁵C regulators were included. Through unsupervised consensus clustering, two clusters with different m⁵C modification patterns were identified with distinct survivals. According to enrichment analyses, glycosaminoglycan and collagen metabolism-related pathways were specif

SUBMITTER: Xu J 

PROVIDER: S-EPMC8971725 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature