Ontology highlight
ABSTRACT:
SUBMITTER: El-Sayes N
PROVIDER: S-EPMC8971726 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
El-Sayes Nader N Walsh Scott S Vito Alyssa A Reihani Amir A Ask Kjetil K Wan Yonghong Y Mossman Karen K
Molecular therapy oncolytics 20220316
Oncolytic virotherapies have shown excellent promise in a variety of cancers by promoting antitumor immunity. However, the effects of oncolytic virus-mediated type I interferon (IFN-I) production on antitumor immunity remain unclear. Recent reports have highlighted immunosuppressive functions of IFN-I in the context of checkpoint inhibitor and cell-based therapies. In this study, we demonstrate that oncolytic virus-induced IFN-I promotes the expression of PD-L1 in tumor cells and leukocytes in a ...[more]