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Self-Sorting Governed by Chelate Cooperativity.

ABSTRACT: Self-sorting phenomena are the basis of manifold relevant (bio)chemical processes where a set of molecules is able to interact with no interference from other sets and are ruled by a number of codes that are programmed in molecular structures. In this work, we study, the relevance of chelate cooperativity as a code for achieving high self-sorting fidelities. In particular, we establish qualitative and quantitative relationships between the cooperativity of a cyclic system and the self-sorting fidelity when combined with other molecules that share identical geometry and/or binding interactions. We demonstrate that only systems displaying sufficiently strong chelate cooperativity can achieve quantitative narcissistic self-sorting fidelities either by dictating the distribution of cyclic species in complex mixtures or by ruling the competition between the intra- and intermolecular versions of a noncovalent interaction.

SUBMITTER: Serrano-Molina D

PROVIDER: S-EPMC8972263 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Self-Sorting Governed by Chelate Cooperativity.

Serrano-Molina David D Montoro-García Carlos C Mayoral María J MJ de Juan Alberto A González-Rodríguez David D

Journal of the American Chemical Society 20220319 12

Self-sorting phenomena are the basis of manifold relevant (bio)chemical processes where a set of molecules is able to interact with no interference from other sets and are ruled by a number of codes that are programmed in molecular structures. In this work, we study, the relevance of chelate cooperativity as a code for achieving high self-sorting fidelities. In particular, we establish qualitative and quantitative relationships between the cooperativity of a cyclic system and the self-sorting fi ...[more]

PMID: 35311263

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