Genetic diversity of human sapovirus across the Americas.

ABSTRACT:

Background

Sapoviruses are responsible for sporadic and epidemic acute gastroenteritis worldwide. Sapovirus typing protocols have a success rate as low as 43% and relatively few complete sapovirus genome sequences are available to improve current typing protocols.

Objective/study design

To increase the number of complete sapovirus genomes to better understand the molecular epidemiology of human sapovirus and to improve the success rate of current sapovirus typing methods, we used deep metagenomics shotgun sequencing to obtain the complete genomes of 68 sapovirus samples from four different countries across the Americas (Guatemala, Nicaragua, Peru and the US).

Results

VP1 genotyping showed that all sapovirus sequences could be grouped in the four established genogroups

SUBMITTER: Diez-Valcarce M 

PROVIDER: S-EPMC8972816 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature