Disease Activity Indices for Pouchitis: A Systematic Review.

ABSTRACT:

Background

Several indices exist to measure pouchitis disease activity; however, none are fully validated. As an initial step toward creating a validated instrument, we identified pouchitis disease activity indices, examined their operating properties, and assessed their value as outcome measures in clinical trials.

Methods

Electronic databases were searched to identify randomized controlled trials including indices that evaluated clinical, endoscopic, or histologic pouchitis disease activity. A second search identified studies that assessed the operating properties of pouchitis indices.

Results

Eighteen randomized controlled trials utilizing 4 composite pouchitis disease activity indices were identified. The Pouchitis Disease Activity Index (PDAI) was most commonly u

SUBMITTER: Sedano R 

PROVIDER: S-EPMC8972820 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature