Isothermal Titration Calorimetry Directly Measures the Selective Swelling of Block Copolymer Vesicles in the Presence of Organic Acid.

ABSTRACT: Block copolymer (BCP) vesicles loaded with drug molecules may have a nonidentical swelling behavior due to the strong interactions between BCP vesicles and loaded molecules. A thermodynamic study of the swelling for such a system is of great importance in clarifying their pH-gated drug delivery behavior. In this study, the selective swelling of polystyrene-block-poly(2-vinylpyridine) (PS-b-P2VP) vesicles in the presence of different acids was compared using dynamic light scattering, zeta-potential, and isothermal titration calorimetry (ITC) measurements. Transmission electron microscopy observation verified that these PS-b-P2VP vesicles were mainly multilamellar. Importantly, using the ITC measurement, we first compared the thermodynamic parameters, including ΔH

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC8973060 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature