Synthesis and evaluation of new chalcones and oximes as anticancer agents.

ABSTRACT: Complex illnesses, such as cancer, are often caused by many disorders, gene mutations, or pathways. Biological pathways play a significant part in the development of these diseases. Multi-target directed ligands (MTDLs) have been used by medicinal chemists recently in an effort to find single molecules that can affect many targets concurrently. In this work, several chalcones containing the ligustrazine moiety were synthesized and tested for their in vitro anticancer activity and several cancer markers, including EGFR, BRAF^V600E, c-Met, and tubulin polymerization, in order to uncover multitarget bioactive compounds. In assays using multiple cancer cell lines, the majority of the compounds examined showed strong anticancer activity against them. To synthesize oximes, all o

SUBMITTER: Bukhari SNA 

PROVIDER: S-EPMC8973297 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature