Kidney Tubulointerstitial Fibrosis and Tubular Secretion.

ABSTRACT:

Rationale & objective

Tubular secretion plays an important role in the efficient elimination of endogenous solutes and medications, and lower secretory clearance is associated with risk of kidney function decline. We evaluated whether histopathologic quantification of interstitial fibrosis and tubular atrophy (IFTA) is associated with lower tubular secretory clearance in persons undergoing kidney biopsy.

Study design

Cross-sectional.

Settings & participants

The Boston Kidney Biopsy Cohort is a study of persons undergoing native kidney biopsies for clinical indications.

Exposures

Semiquantitative score of IFTA reported by 2 trained pathologists.

Outcomes

We measured plasma and urine concentrations of 9 endogenous secretory solutes using a targeted liquid

SUBMITTER: Garimella PS 

PROVIDER: S-EPMC8973399 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature