International Union of Basic and Clinical Pharmacology. CXII: Adenosine Receptors: A Further Update.

ABSTRACT: Our previous International Union of Basic and Clinical Pharmacology report on the nomenclature and classification of adenosine receptors (2011) contained a number of emerging developments with respect to this G protein-coupled receptor subfamily, including protein structure, protein oligomerization, protein diversity, and allosteric modulation by small molecules. Since then, a wealth of new data and results has been added, allowing us to explore novel concepts such as target binding kinetics and biased signaling of adenosine receptors, to examine a multitude of receptor structures and novel ligands, to gauge new pharmacology, and to evaluate clinical trials with adenosine receptor ligands. This review should therefore be considered a further update of our previous reports from 2001 and 201

SUBMITTER: IJzerman AP 

PROVIDER: S-EPMC8973513 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature