Dynamics of nuclear matrix attachment regions during 5^th instar posterior silk gland development in Bombyx mori.

ABSTRACT:

Background

Chromatin architecture is critical for gene expression during development. Matrix attachment regions (MARs) control and regulate chromatin dynamics. The position of MARs in the genome determines the expression of genes in the organism. In this study, we set out to elucidate how MARs temporally regulate the expression of the fibroin heavy chain (FIBH) gene during development. We addressed this by identifying MARs and studying their distribution and differentiation, in the posterior silk glands of Bombyx mori during 5th instar development.

Results

Of the MARs identified on three different days, 7.15% MARs were common to all 3 days, whereas, 1.41, 19.27 and 52.47% MARs were unique to day 1, day 5, and day 7, respectively highlighting the dynamic nature of the matrix

SUBMITTER: Chunduri AR 

PROVIDER: S-EPMC8973518 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature