A novel HIF1α-STIL-FOXM1 axis regulates tumor metastasis.

ABSTRACT:

Background

Metastasis is the major cause of morbidity and mortality in cancer that involves in multiple steps including epithelial-mesenchymal transition (EMT) process. Centrosome is an organelle that functions as the major microtubule organizing center (MTOC), and centrosome abnormalities are commonly correlated with tumor aggressiveness. However, the conclusive mechanisms indicating specific centrosomal proteins participated in tumor progression and metastasis remain largely unknown.

Methods

The expression levels of centriolar/centrosomal genes in various types of cancers were first examined by in silico analysis of the data derived from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and European Bioinformatics Institute (EBI) datasets. The expression of ST

SUBMITTER: Wang YW 

PROVIDER: S-EPMC8973879 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature