Chromatin-remodeling factor CHR721 with non-canonical PIP-box interacts with OsPCNA in Rice.

ABSTRACT:

Background

Proliferating cell nuclear antigen (PCNA) is one of the key factors for the DNA replication process and DNA damage repair. Most proteins interacting with PCNA have a common binding motif: PCNA interacting protein box (PIP box). However, some proteins with non-canonical PIP-box have also been reported to be the key factors that interacted with PCNA.

Results

Here we discovered the C terminal of a chromatin-remodeling factor CHR721 with non-canonical PIP-box was essential for interacting with OsPCNA in rice. Both OsPCNA and CHR721 were localized in the nuclei and function in response to DNA damages.

Conclusions

Based on the results and previous work, we proposed a working model that CHR721 with non-canonical PIP-box interacted with OsPCNA and both of them prob

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8974069 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature