From non-targeted to targeted GC-MS metabolomics strategy for identification of TCM preparations containing natural and artificial musk.

ABSTRACT:

Background

Moschus is a rare and precious natural medicine. Due to the properties of resources scarcity and expensive price of natural musk, artificial musk has been developed as substitute materials in some prescriptions. Rapid and accurate identification of natural or artificial musk in complex traditional Chinese medicine (TCM) preparations is also a challenge.

Method

A strategy from non-targeted to targeted gas chromatography-mass spectrometry (GC-MS) metabolomics was developed for discrimination of natural and artificial musk. Firstly, GC-MS-based non-targeted analysis combined with chemometrics was used to find the potential chemical markers to distinguish natural musk and artificial musk. Subsequently, targeted metabolomics was used to analyze musk in preparations wit

SUBMITTER: Ding M 

PROVIDER: S-EPMC8974109 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature