Programmed Cell Death-1 and Its Ligands as Targets for Therapy of Multiple Myeloma Patients.

ABSTRACT:

Purpose

Among hematological malignancies, the expression profile of programmed cell death-1 (PD-1) and its ligands in multiple myeloma (MM) is still debated by numerous research groups. In current study, we characterized the expression of PD-1 and its ligands both on RNA and protein levels in MM patients. We have also attempted to analyze whether daratumumab therapy might overcome CD38-mediated immunosuppression that inhibits in particular CD8+ T-cell function.

Patients and methods

This study included 149 newly diagnosed MM patients and 15 relapsed/refractory MM patients before and after daratumumab treatment. The mRNA levels of PDCD1, PDCD1LG1, PDCD1LG2 and their splicing variants was assessed by quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR).

SUBMITTER: Karczmarczyk A 

PROVIDER: S-EPMC8974248 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature