Mild Parkinsonian Signs, Energy Decline, and Striatal Volume in Community-Dwelling Older Adults.

ABSTRACT:

Background

Mild parkinsonian signs (MPS), highly prevalent in older adults, predict disability. It is unknown whether energy decline, a predictor of mobility disability, is also associated with MPS. We hypothesized that those with MPS had greater decline in self-reported energy level (SEL) than those without MPS, and that SEL decline and MPS share neural substrates.

Method

Using data from the Health, Aging and Body Composition Study, we analyzed 293 Parkinson's disease-free participants (83 ± 3 years old, 39% Black, 58% women) with neuroimaging data, MPS evaluation by Unified Parkinson Disease Rating Scale in 2006-2008, and ≥3 measures of SEL since 1999-2000. Individual SEL slopes were computed via linear mixed models. Associations of SEL slopes with MPS were tested using lo

SUBMITTER: Tian Q 

PROVIDER: S-EPMC8974349 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature