Intratumor CMS Heterogeneity Impacts Patient Prognosis in Localized Colon Cancer.

ABSTRACT:

Purpose

The consensus molecular subtypes (CMS) represent a significant advance in the understanding of intertumor heterogeneity in colon cancer. Intratumor heterogeneity (ITH) is the new frontier for refining prognostication and understanding treatment resistance. This study aims at deciphering the transcriptomic ITH of colon cancer and understanding its potential prognostic implications.

Experimental design

We deconvoluted the transcriptomic profiles of 1,779 tumors from the PETACC8 trial and 155 colon cancer cell lines as weighted sums of the four CMSs, using the Weighted In Silico Pathology (WISP) algorithm. We assigned to each tumor and cell line a combination of up to three CMS subtypes with a threshold above 20%.

Results

Over 55% of tumors corresponded to mixtur

SUBMITTER: Marisa L 

PROVIDER: S-EPMC8974433 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature