Purinergic Receptors in the Airways: Potential Therapeutic Targets for Asthma?

ABSTRACT: Extracellular ATP functions as a signaling messenger through its actions on purinergic receptors, and is known to be involved in numerous physiological and pathophysiological processes throughout the body, including in the lungs and airways. Consequently, purinergic receptors are considered to be promising therapeutic targets for many respiratory diseases, including asthma. This review explores how online bioinformatics resources combined with recently generated datasets can be utilized to investigate purinergic receptor gene expression in tissues and cell types of interest in respiratory disease to identify potential therapeutic targets, which can then be investigated further. These approaches show that different purinergic receptors are expressed at different levels in lung tissue, and t

SUBMITTER: Thompson RJ 

PROVIDER: S-EPMC8974712 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature