The Arg82Cys Polymorphism of the Protein Nepmucin Implies a Role in HDL Metabolism.

ABSTRACT:

Context

Blood lipid levels are linked to the risk of cardiovascular disease and regulated by genetic factors. A low-frequency polymorphism Arg82Cys (rs72836561) in the membrane protein nepmucin, encoded by CD300LG, is associated with lower fasting concentration of high-density lipoprotein cholesterol (HDLc) and higher fasting triglycerides. However, whether the variant is linked to postprandial lipids and glycemic status remains elusive.

Objective

Here, we augment the genetic effect of Arg82Cys on fasting plasma concentrations of HDL subclasses, postprandial lipemia after a standardized high-fat meal, and glycemic status to further untangle its role in HDL metabolism.

Methods

We elucidated fasting associations with HDL subclasses in a population-based cohort st

SUBMITTER: Metz S 

PROVIDER: S-EPMC8974852 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature