Impact of Intestinal Bacteria on Levodopa Pharmacokinetics in LCIG Therapy.

ABSTRACT:

Background

Levodopa-carbidopa intestinal gel (LCIG) therapy is used in advanced Parkinson's disease (PD) and consists of continuous administration of levodopa directly into the jejunum through a percutaneous endoscopic gastro-jejunal (PEG-J) tube. Recently, the metabolism of levodopa by Enterococcus faecalis (E. faecalis) has been reported. Intestinal bacteria can also affect this therapy.

Objectives

To investigate intestinal bacteria and examine its impact on levodopa blood concentration in patients with PD receiving LCIG therapy.

Methods

We enrolled 6 patients receiving LCIG therapy in our department. After PEG-J tube replacement, intestinal bacteria were collected from the tip of the tube and were identified using culture and polymerase chain reaction

SUBMITTER: Yamanishi Y 

PROVIDER: S-EPMC8974876 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature