Multimodal pain assessment improves discrimination between noxious and non-noxious stimuli in infants.

ABSTRACT: Infants in neonatal intensive care units frequently experience clinically necessary painful procedures, which elicit a range of behavioral, physiological, and neurophysiological responses. However, the measurement of pain in this population is a challenge and no gold standard exists. The aim of this study was to investigate how noxious-evoked changes in facial expression, reflex withdrawal, brain activity, heart rate, and oxygen saturation are related and to examine their accuracy in discriminating between noxious and non-noxious stimuli. In 109 infants who received a clinically required heel lance and a control non-noxious stimulus, we investigated whether combining responses across each modality, or including multiple measures from within each modality improves our ability to discriminat

SUBMITTER: van der Vaart M 

PROVIDER: S-EPMC8974881 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature