The effect of decellularisation on the real time mechanical fatigue of porcine aortic heart valve roots.

ABSTRACT: Decellularised heart valve roots offer a promising option for heart valve replacement in young patients, having the potential to remodel and repair. Replacement heart valves have to undergo billions of opening and closing cycles throughout the patient's lifetime. Therefore, understanding the effect of cyclic loading on decellularised heart valve roots is important prior to human implantation. The aim of this preliminary study was to investigate the influence of low concentration sodium dodecyl sulphate (SDS) decellularisation treatment on the in vitro real time mechanical fatigue of porcine aortic heart valve roots under physiological real time cyclic loading conditions. This required a specific real time in vitro method to be developed, since previous methods relied on accelerated testing

SUBMITTER: Desai A 

PROVIDER: S-EPMC8974965 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature