Molecular alterations in the integrated diagnosis of pediatric glial and glioneuronal tumors: A single center experience.

ABSTRACT:

Objectives

Tumors of the central nervous system (CNS) are the most common pediatric solid tumors, where low grade (LGG) and high grade gliomas (HGG) represent up to 55% of CNS tumors. Current molecular classification of these tumors results in a more accurate diagnosis and risk stratification, which ultimately enables individualized treatment strategies. Identifying known alterations is a suitable approach, particularly in developing countries, where NGS approaches are not easily accessible. We sought to assess molecular alterations in BRAF and histone 3 genes.

Study design

FISH, IHC and Sanger sequencing were performed in a series of 102 pediatric glial and glioneuronal tumors. We also correlated these results with clinical and histological findings to evaluate their useful

SUBMITTER: Colli SL 

PROVIDER: S-EPMC8975011 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature