Inflammatory Cells in Nephrectomy Tissue from Patients without and with a History of Urinary Stone Disease.

ABSTRACT:

Background and objectives

Urinary stone disease has been associated with inflammation, but the specific cell interactions that mediate events remain poorly defined. This study compared calcification and inflammatory cell patterns in kidney tissue from radical nephrectomy specimens of patients without and with a history of urinary stone disease.

Design, setting, participants, & measurements

Nontumor parenchyma of biobanked radical nephrectomy specimens from age- and sex-matched stone formers (n=44) and nonstone formers (n=82) were compared. Calcification was detected by Yasue staining and inflammatory cell populations by immunohistochemistry for CD68 (proinflammatory M1 macrophages), CD163 and CD206 (anti-inflammatory M2 macrophages), CD3 (T lymphocytes), and tr

SUBMITTER: Dejban P 

PROVIDER: S-EPMC8975022 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature