Potential Effects of Elimination of the Black Race Coefficient in eGFR Calculations in the CREDENCE Trial.

ABSTRACT:

Background and objectives

The effect of including race in the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation on screening, recruitment, and outcomes of clinical trials is unclear.

Design, setting, participants, & measurements

The inclusion and outcomes of participants in the Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) trial, which randomized individuals with type 2 diabetes and CKD to canagliflozin or placebo, were evaluated after calculating eGFR using the 2009 CKD-EPI creatinine equation with and without a race-specific coefficient or the 2021 CKD-EPI creatinine equation. Treatment effects were estimated using proportional hazards models and piecewise linear mixed effects models for eGFR slope

SUBMITTER: Charytan DM 

PROVIDER: S-EPMC8975029 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature