Natural History of Bone Disease following Kidney Transplantation.

ABSTRACT:

Background

Knowledge of the effect of kidney transplantation on bone is limited and fragmentary. The aim of this study was to characterize the evolution of bone disease in the first post-transplant year.

Methods

We performed a prospective, observational cohort study in patients referred for kidney transplantation under a steroid-sparing immunosuppressive protocol. Bone phenotyping was done before, or at the time of, kidney transplantation, and repeated at 12 months post-transplant. The phenotyping included bone histomorphometry, bone densitometry by dual-energy x-ray absorptiometry, and biochemical parameters of bone and mineral metabolism.

Results

Paired data were obtained for 97 patients (median age 55 years; 72% male; 21% of patients had diabetes). Bone turnover re

SUBMITTER: Jorgensen HS 

PROVIDER: S-EPMC8975071 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature