Assessment of the Relationship between Ulcerative Colitis and Forkhead Box P3 Polymorphisms.

ABSTRACT:

Background/aims

Ulcerative colitis (UC) is a chronic disease that does not have a definitive treatment and causes repetitive inflammation of the colon and impaired quality of life. The FOXP3 gene codes FOXP3 protein responsible for development and function of regulatory T (Treg) cells. The rs2232365 A/G and the rs3761548 A/C polymorphisms of FOXP3 gene were indicated to be associated with inflammation-related diseases such as ulcerative colitis. The effectiveness of Treg cells, which act as immune-suppressors in the control of inflammation, can be affected by these polymorphisms. The aim of the present study was to evaluate the association between these polymorphisms with ulcerative colitis.

Materials and methods

The current study researched the FOXP3 gene polymorphisms in 1

SUBMITTER: Ulger Y 

PROVIDER: S-EPMC8975443 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature