Are Pattern Recognition Receptors Associated with Hepatocellular Carcinoma?

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is one of the important causes of mortality due to malignancy. Toll-like receptors (TLRs) are very important in liver pathophysiology in terms of their roles in the innate immune system, such as the regulation of inflammation, wound healing, stimulation of adaptive immune responses, promotion of epithelial regeneration, and carcinogenesis. In this study, we planned to examine the role of TLR1 (rs4833095, rs5743551) and nucleotide-binding oligomerization domain (NOD2) (rs2066844, rs2066845, rs2066847) polymorphisms in the development of HCC and their effects on the clinical presentation of HCC patients.

Methods

Our study was designed prospectively. Cirrhotic and HCC patients who were followed up in our clinic between January 2015 and

SUBMITTER: Dertli R 

PROVIDER: S-EPMC8975513 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature