Mendelian randomization suggests a bidirectional, causal relationship between physical inactivity and adiposity.

ABSTRACT: Physical inactivity and increased sedentary time are associated with excess weight gain in observational studies. However, some longitudinal studies indicate reverse causality where weight gain leads to physical inactivity and increased sedentary time. As observational studies suffer from reverse causality, it is challenging to assess the true causal directions. Here, we assess the bidirectional causality between physical inactivity, sedentary time, and adiposity by bidirectional Mendelian randomization analysis. We used results from genome-wide association studies for accelerometer-based physical activity and sedentary time in 91,105 individuals and for body mass index (BMI) in 806,834 individuals. We implemented Mendelian randomization using CAUSE method that accounts for pleiotropy and

SUBMITTER: Carrasquilla GD 

PROVIDER: S-EPMC8975550 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature