Developmental pyrethroid exposure and age influence phenotypes in a Chd8 haploinsufficient autism mouse model.

ABSTRACT: Hundreds of genes have been associated with autism spectrum disorder (ASD), including loss-of-function mutations in chromodomain helicase DNA binding protein 8 (Chd8). Environmental factors also are implicated in autism risk and have the potential to exacerbate phenotypes in genetically sensitized backgrounds. Here we investigate transcriptional and behavioral phenotypes in a Chd8 haploinsufficient (Chd8^V986*/+) mouse line exposed to the pesticide deltamethrin (DM) from conception to postnatal day 22. Vehicle-exposed Chd8^V986*/+ mice displayed ASD-associated phenotypes, including anxiety-like behavior and altered sociability, replicating a previous study with this mouse line. A core set of genes was altered in Chd8^V986*/+ mice at multiple ages, including Us

SUBMITTER: Jimenez JA 

PROVIDER: S-EPMC8975859 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature