In vivo vesicular acetylcholine transporter density in human peripheral organs: an [¹⁸F]FEOBV PET/CT study.

ABSTRACT:

Background

The autonomic nervous system is frequently affected in some neurodegenerative diseases, including Parkinson's disease and Dementia with Lewy bodies. In vivo imaging methods to visualize and quantify the peripheral cholinergic nervous system are lacking. By using [¹⁸F]FEOBV PET, we here describe the peripheral distribution of the specific cholinergic marker, vesicular acetylcholine transporters (VAChT), in human subjects. We included 15 healthy subjects aged 53-86 years for 70 min dynamic PET protocol of peripheral organs. We performed kinetic modelling of the adrenal gland, pancreas, myocardium, renal cortex, spleen, colon, and muscle using an image-derived input function from the aorta. A metabolite correction model was generated from venous blood samples. Th

SUBMITTER: Horsager J 

PROVIDER: S-EPMC8975951 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature