Association of Adjuvant Chemotherapy With Overall Survival Among Patients With Locally Advanced Gastric Cancer After Neoadjuvant Chemotherapy.

ABSTRACT:

Importance

Neoadjuvant chemotherapy (NAC) is a standard treatment option for locally advanced gastric cancer (LAGC); however, the indications for adjuvant chemotherapy (AC) in patients with LAGC who received NAC remain controversial.

Objective

To compare survival rates between patients with LAGC who received AC and those who did not after NAC followed by surgery.

Design, setting, and participants

This multicenter, international cohort study included 353 patients with LAGC undergoing curative-intent gastrectomy after NAC at 2 tertiary referral teaching hospitals in China between June 1, 2008, and December 31, 2017. To externally validate the findings in the Chinese patients, 109 patients from the US and Italy between June 1, 2006, and June 30, 2013, were reviewed. The

SUBMITTER: Lin JX 

PROVIDER: S-EPMC8976237 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature