Hesperidin identified from Citrus extracts potently inhibits HCV genotype 3a NS3 protease.

ABSTRACT:

Background

Hepatitis C virus infection is the main cause of liver ailments across the globe. Several HCV genotypes have been identified in different parts of the world. Effective drugs for combating HCV infections are available but not affordable, particularly to infected individuals from resource-limited countries. Hence, cost-effective drugs need to be developed against important HCV drug targets. As Citrus fruits naturally contain bioactive compounds with antiviral activities, the current study was designed to identify antiviral inhibitors from Citrus fruit extracts against an important drug target, NS3 protease, of HCV genotype 3a which is found predominantly in South Asian countries.

Methods

The full-length NS3 protease alone and the NS3 protease domain in fusion with t

SUBMITTER: Khan M 

PROVIDER: S-EPMC8976278 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature