Clinicopathologic predictors of central lymph node metastases in clinical node-negative papillary thyroid microcarcinoma: a systematic review and meta-analysis.

ABSTRACT:

Background

The presence of central lymph node metastases (CLNM) has been suggested as a risk factor for poorer prognosis and recurrence in papillary thyroid microcarcinoma (PTMC). However, the clinicopathologic factors for CLNM in clinical node-negative (CN0) PTMC were not well defined. This study aimed to perform a systematic review and meta-analysis to investigate the significant clinicopathologic predictors of CLNM in CN0 PTMC.

Methods

A systematic literature search was performed in PubMed, Embase, Cochrane Library, and Web of Science. Case-control studies on the association of clinicopathologic risk factors with CLNM in CN0 PTMC were included.

Results

Thirteen eligible studies involving 6068 patients with CN0 PTMC were included. From the pooled analyses, male (odd

SUBMITTER: Wen X 

PROVIDER: S-EPMC8976349 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature