Autophagy-mediated expression clusters are involved in immunity regulation of coronary artery disease.

ABSTRACT:

Background

The association between autophagy and immunity, including infiltrating immunocytes, immune reaction gene-sets, and HLAs (human leukocyte antigen) gene, remains unclear. The present study aimed to provide a valid diagnostic tool for coronary artery disease (CAD), and explore the pathological mechanisms of CAD based on the association between autophagy and immunity.

Methods

First, the overlap between differentially expressed genes (DEGs) and autophagy-related genes (ARGs) was identified. Subsequently, machine learning was conducted to screen risk genes closely related to CAD. Diverse autophagy phenotype-related clusters were identified using unsupervised clustering. The connections between different clusters and immune characteristics were evaluated as well.

Resu

SUBMITTER: Lv J 

PROVIDER: S-EPMC8976398 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature