Associations of carotid intima media thickness with gene expression in whole blood and genetically predicted gene expression across 48 tissues.

ABSTRACT: Carotid intima media thickness (cIMT) is a biomarker of subclinical atherosclerosis and a predictor of future cardiovascular events. Identifying associations between gene expression levels and cIMT may provide insight to atherosclerosis etiology. Here, we use two approaches to identify associations between mRNA levels and cIMT: differential gene expression analysis in whole blood and S-PrediXcan. We used microarrays to measure genome-wide whole blood mRNA levels of 5647 European individuals from four studies. We examined the association of mRNA levels with cIMT adjusted for various potential confounders. Significant associations were tested for replication in three studies totaling 3943 participants. Next, we applied S-PrediXcan to summary statistics from a cIMT genome-wide association stu

SUBMITTER: Castaneda AB 

PROVIDER: S-EPMC8976428 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature