Dataset Information

Effect of β3-adrenergic receptor gene polymorphism and lifestyle on overweight Japanese rural residents: A cross-sectional study.

ABSTRACT:

Objectives

The β3-adrenergic receptor (ADRB3) gene polymorphism has been implicated in obesity. Therefore, the contribution of ADRB3 Trp64Arg polymorphism to obesity-related indicators was investigated, taking into account the lifestyle-related factors in a Japanese rural population.

Methods

A total of 600 Japanese adults aged ≥40 years in a population-based cohort study were analyzed. The ADRB3 polymorphism was determined using peripheral blood samples. Associations between genotype and body mass index (BMI), waist circumference (WC), and body fat (BF) percentage were examined, adjusting for lifestyle-related factors, including daily nutrient intake.

Results

The frequency of Arg64 allele carriers was 36%. There was no significant difference in BMI, WC, or BF between the groups with or without the Trp64Arg polymorphism. Multivariable logistic regression analysis showed that the Trp64Arg polymorphism was not associated with these three indicators, but lifestyle factors including physical inactivity, higher energy and sodium consumption, and less animal protein intake were significantly related to increased WC and BF percentages.

Conclusions

The Trp64Arg polymorphism of ADRB3 gene did not contribute to increased BMI, WC, or BF. However, lifestyle-related factors impacted these indicators in middle-aged and older Japanese individuals living in rural areas.

SUBMITTER: Hara A

PROVIDER: S-EPMC8976547 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Publications

Effect of β3-adrenergic receptor gene polymorphism and lifestyle on overweight Japanese rural residents: A cross-sectional study.

Hara Akinori A Nguyen Phat Minh PM Tsujiguchi Hiromasa H Nakamura Masaharu M Yamada Yohei Y Suzuki Keita K Suzuki Fumihiko F Kasahara Tomoko T Pham Oanh Kim OK Nakamura Haruki H Kambayashi Yasuhiro Y Shimizu Yukari Y Nguyen Thao Thi Thu TTT Miyagi Sakae S Kannon Takayuki T Sato Takehiro T Hosomichi Kazuyoshi K Tajima Atsushi A Nakamura Hiroyuki H

Obesity science & practice 20210921 2

<h4>Objectives</h4>The β3-adrenergic receptor (<i>ADRB3</i>) gene polymorphism has been implicated in obesity. Therefore, the contribution of <i>ADRB3</i> Trp64Arg polymorphism to obesity-related indicators was investigated, taking into account the lifestyle-related factors in a Japanese rural population.<h4>Methods</h4>A total of 600 Japanese adults aged ≥40 years in a population-based cohort study were analyzed. The <i>ADRB3</i> polymorphism was determined using peripheral blood samples. Assoc ...[more]

PMID: 35388349

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Dataset Information

Effect of β3-adrenergic receptor gene polymorphism and lifestyle on overweight Japanese rural residents: A cross-sectional study.

Objectives

Methods

Results

Conclusions

Publications

Effect of β3-adrenergic receptor gene polymorphism and lifestyle on overweight Japanese rural residents: A cross-sectional study.

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