The Role of PDGFRA in Predicting Oncological and Immune Characteristics in Pancreatic Ductal Adenocarcinoma.

ABSTRACT:

Objective

Pancreatic ductal adenocarcinoma (PDAC) is a lethal solid gastrointestinal malignancy with poor immune infiltration and a limited response to immunotherapy. The aim of our study was to explore the predictive value of platelet-derived growth factors (PDGFs) and their receptors (PDGFRs), which are widely expressed in various tumor cells.

Methods

Transcriptomic data with follow-up information were obtained from the GEO, TCGA and ArrayExpress. The Kaplan-Meier (KM) method and univariate Cox (UniCox) proportional hazard regression were used to show the survival outcomes of the groups. Immune infiltration was analyzed using the online databases TISCH, TISIDB, TIMER2.0, and TIDE as well as the R packages "estimate" and "GSVA." Mutation and functional enrichment analyses w

SUBMITTER: Wu Z 

PROVIDER: S-EPMC8976608 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature