Concordance of Peripheral Blood and Bone Marrow Next-Generation Sequencing in Hematologic Neoplasms.

ABSTRACT:

Objective

Mutational analysis by next-generation sequencing (NGS) obtained by peripheral blood NGS has been of clinical interest to use as a minimally invasive screening tool. Our study evaluates the correlation between NGS results on peripheral blood and bone marrow in hematolymphoid disease.

Method

We evaluated patients who had NGS for presumed hematologic malignancy performed on peripheral blood and bone marrow within a 1-year interval of each other. We excluded cases in which chemotherapy or bone marrow transplant occurred in the interval between the two tests. The concordance across peripheral blood and bone marrow NGS results was assessed by kappa coefficient analysis.

Results

A total of 163 patients were studied. Concordance of peripheral blood and bone marrow

SUBMITTER: Jumniensuk C 

PROVIDER: S-EPMC8976630 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature